Pathogenic strains of Acinetobacter baumannii excrete multiple siderophores that enhance
iron scavenging from host sources. The oxazoline siderophore pre-acinetobactin undergoes …

The rise of antibiotic resistant bacteria has become a problem of global concern. Of
particular interest are the ESKAPE pathogens, species with high rates of multi-drug resistant …

Isonitrile natural products exhibit promising antibacterial activities. However, their mechanism
of action (MoA) remains largely unknown. Based on the nanomolar potency of xanthocillin …

The need to support innovation in health care delivery was prompted by payment reforms
and access to digital tools and has been accelerated by the shift to virtual care as part of the …

The emergence of multidrug resistant (MDR) Gram-negative bacterial pathogens has raised
global concern. Nontraditional therapeutic strategies, including antivirulence approaches, …

Pathogenic Acinetobacter baumannii excrete the siderophore pre-acinetobactin as an iron-scavenging
virulence factor. Pre-acinetobactin is a 2,3-dihydroxy-phenyl oxazoline that …

Background: The COVID-19 pandemic has exacerbated pre-existing challenges with respect
to access to elective surgery across Canada, and a single-entry model (SEM) approach …

The critical role that iron plays in many biochemical processes has led to an elaborate battle
between bacterial pathogens and their hosts to acquire and withhold this critical nutrient. …

Objectives: The cost-effectiveness of bilateral cochlear implants in adults remains uncertain
despite established clinical benefits. In cost-effectiveness studies, benefit is often measured …

Importance Postoperative radiation therapy for close surgical margins in low- to intermediate-grade
salivary carcinomas lacks multi-institutional supportive evidence. Objective To …