Background: Many medications pose greater health risks when prescribed for older adults,
compared with available pharmacologic and nonpharmacologic alternatives. We sought to …

The toll-like receptor 7 and 8 (TLR7/8) agonist Resiquimod (R848) has been recognized as
a promising immunostimulator for the treatment of cutaneous cancers in multiple clinical trials…

Background The Canadian opioid crisis is a complex, multifaceted problem involving
prescribed, diverted and illicitly manufactured opioids. This study sought to characterize the …

A palladium‐catalyzed decarboxylative benzylation reaction of α,α‐difluoroketone enolates
is reported, in which the key C(α)−C(sp 3 ) bond is generated by reductive elimination from a …

Purpose Incident investigation, reporting, and learning are core elements of quality improvement
in radiation treatment. This report describes the development of a Canadian National …

Small molecule agonists of TLR7/8, such as imidazoquinolines, are validated agonists for
the treatment of cancer and for use in vaccine adjuvants. Imidazoquinolines have been …

Excerpt The pathological changes of pulmonary infarction were known to Laennec, but he
failed to recognize the relationship between embolism and infarction and called the condition "…

As they age, many seniors develop a progressively more complex mix of health conditions.
Multiple prescription medications are often required to help manage these conditions and …

Background Public drug coverage for triptan medications varies across jurisdictions in C
anada, which may lead to differences in usage patterns and patient risk for medication overuse …

Animal Behaviour deal with the field of animal behaviour an exploration of the mental
experiences of animals, particularly as they behave in their natural environment in the course of …