Objectives. —To improve end-of-life decision making and reduce the frequency of a mechanically
supported, painful, and prolonged process of dying. Design. —A 2-year prospective …

Background Obesity prevalence has increased during the past decades in children and
adolescents, leading to a significant current and future health burden.

Current rates of climate change require organisms to respond through migration, phenotypic
plasticity, or genetic changes via adaptation. We focused on questions regarding species’ …

Importance The sequelae of gestational diabetes (GD) by contemporary criteria that diagnose
approximately twice as many women as previously used criteria are unclear. Objective To …

OBJECTIVE Whether hyperglycemia in utero less than overt diabetes is associated with
altered childhood glucose metabolism is unknown. We examined associations of gestational …

The utility of the disposition index as a measure of β‐cell compensatory capacity rests on the
established hyperbolic relationship between its component insulin secretion and sensitivity …

Maternally synthesized RNAs program early embryonic development in many animals. These
RNAs are degraded rapidly by the midblastula transition (MBT), allowing genetic control of …

OBJECTIVE To determine in Canadian children aged <18 years the 1) incidence of type 2
diabetes, medication-induced diabetes, and monogenic diabetes; 2) clinical features of type 2 …

OBJECTIVE This study examined associations of maternal glycemia during pregnancy with
childhood glucose outcomes in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO…

Aims/hypothesis Maternal type 2 diabetes during pregnancy and gestational diabetes are
associated with childhood adiposity; however, associations of lower maternal glucose levels …