… Author links open overlay panel Holger J. … Schünemann H, Brożek J, Oxman A. GRADE
handbook for grading quality of evidence and strength of recommendation. Version 3.2 [updated …

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
COVID-19 and is spread person-to-person through close contact. We aimed to investigate the …

Background Allergic rhinitis (AR) affects 10% to 40% of the population. It reduces quality of
life and school and work performance and is a frequent reason for office visits in general …

This document is an international evidence-based guideline on the diagnosis and management
of idiopathic pulmonary fibrosis, and is a collaborative effort of the American Thoracic …

… The members of the Grade Working Group are Phil Alderson, Pablo Alonso-Coello, Jeff
Andrews, David Atkins, Hilda Bastian, Hans de Beer, Jan Brozek, Francoise Cluzeau, Jonathan …

BACKGROUND: Allergic rhinitis represents a global health problem affecting 10% to 20% of
the population. The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines have been …

GRADE suggests that examination of 95% confidence intervals (CIs) provides the optimal
primary approach to decisions regarding imprecision. For practice guidelines, rating down the …

In the GRADE approach, randomized trials start as high-quality evidence and observational
studies as low-quality evidence, but both can be rated down if most of the relevant evidence …

In the GRADE approach, the strength of a recommendation reflects the extent to which we
can be confident that the composite desirable effects of a management strategy outweigh the …

Non-randomised studies of the effects of interventions are critical to many areas of healthcare
evaluation, but their results may be biased. It is therefore important to understand and …