Background In the context of clinical research, investigators have historically selected the
outcomes that they consider to be important, but these are often discordant with patients’ …

Background Survival and quality of life for patients on hemodialysis therapy remain poor
despite substantial research efforts. Existing trials often report surrogate outcomes that may not …

Evidence-informed decision making in clinical care and policy in nephrology is undermined
by trials that selectively report a large number of heterogeneous outcomes, many of which …

Objective The main objective of this study was to summarize the effects of various individual,
caregiver, and system‐related factors on the risk of long‐term care (LTC) placement for …

There is general agreement that frailty is a state of heightened vulnerability to stressors
arising from impairments in multiple systems leading to declines in homeostatic reserve and …

Objectives The objective of our study is to evaluate the effectiveness of dementia case
management compared with usual care on reducing long‐term care placement, hospitalization, …

Background: The importance of engaging key stakeholders, and patients in particular, in
determining research priorities has been recognized. We sought to identify the top 10 research …

Background Inconsistencies in outcome reporting and frequent omission of patient-centered
outcomes can diminish the value of trials in treatment decision making. We identified …

Background: Little is known about how multimorbidity, dementia and increasing age
combine to influence health outcomes or utilization. Our objective was to examine the joint …

Rationale & Objective Fostering the ability of patients to self-manage their chronic kidney
disease (CKD), with support from caregivers and providers, may slow disease progression and …