User profiles for Helen Dimaras
 | Helen DimarasAssociate Professor, Ophthalmology, University of Toronto | Scientist, CHES Program … Verified email at utoronto.ca Cited by 4593 |
[HTML][HTML] Retinoblastoma
Retinoblastoma is an aggressive eye cancer of infancy and childhood. Survival and the chance
of saving vision depend on severity of disease at presentation. Retinoblastoma was the …
of saving vision depend on severity of disease at presentation. Retinoblastoma was the …
Global retinoblastoma presentation and analysis by national income level
…, L Desjardins, RYD Coronado, H Dimaras… - JAMA …, 2020 - jamanetwork.com
Importance Early diagnosis of retinoblastoma, the most common intraocular cancer, can
save both a child’s life and vision. However, anecdotal evidence suggests that many children …
save both a child’s life and vision. However, anecdotal evidence suggests that many children …
[HTML][HTML] Views from the global south: exploring how student volunteers from the global north can achieve sustainable impact in global health
BDO Ouma, H Dimaras - Globalization and Health, 2013 - Springer
Background The body of research and practice regarding student volunteer abroad experiences
largely focuses on ensuring the optimal learning experience for the student from the …
largely focuses on ensuring the optimal learning experience for the student from the …
Retinoblastoma
Retinoblastoma is a rare cancer of the infant retina that is diagnosed in approximately 8,000
children each year worldwide. It forms when both retinoblastoma gene (RB1) alleles are …
children each year worldwide. It forms when both retinoblastoma gene (RB1) alleles are …
[HTML][HTML] Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies
…, NL Prigoda-Lee, C Spencer, H Dimaras… - The lancet …, 2013 - thelancet.com
Background Retinoblastoma is the childhood retinal cancer that defined tumour-suppressor
genes. Previous work shows that mutation of both alleles of the RB1 retinoblastoma …
genes. Previous work shows that mutation of both alleles of the RB1 retinoblastoma …
Loss of RB1 induces non-proliferative retinoma: increasing genomic instability correlates with progression to retinoblastoma
Retinoblastoma clinical observations revealed the role of tumor suppressor genes in human
cancer, Knudson's ‘two-hit’ model of cancer induction. We now demonstrate that loss of both …
cancer, Knudson's ‘two-hit’ model of cancer induction. We now demonstrate that loss of both …
[PDF][PDF] Binary pan-cancer classes with distinct vulnerabilities defined by pro-or anti-cancer YAP/TEAD activity
Cancer heterogeneity impacts therapeutic response, driving efforts to discover over-arching
rules that supersede variability. Here, we define pan-cancer binary classes based on distinct …
rules that supersede variability. Here, we define pan-cancer binary classes based on distinct …
The genomic landscape of retinoblastoma: a review
Retinoblastoma is a paediatric ocular tumour that continues to reveal much about the genetic
basis of cancer development. Study of genomic aberrations in retinoblastoma tumours has …
basis of cancer development. Study of genomic aberrations in retinoblastoma tumours has …
Retinoblastoma, the visible CNS tumor: a review
The pediatric ocular cancer retinoblastoma is the only central nervous system (CNS) tumor
readily observed without specialized equipment: it can be seen by, and in, the naked eye. …
readily observed without specialized equipment: it can be seen by, and in, the naked eye. …
Intra-arterial chemotherapy for retinoblastoma: a systematic review
…, PPP Astudillo, P Durairaj, H Dimaras… - JAMA …, 2016 - jamanetwork.com
Importance Intra-arterial chemotherapy has emerged as a treatment for intraocular
retinoblastoma and has been quickly adopted by centers worldwide. Objective To conduct a …
retinoblastoma and has been quickly adopted by centers worldwide. Objective To conduct a …