Objective To compare the effects of treatments for coronavirus disease 2019 (covid-19).
Design Living systematic review and network meta-analysis. Data sources WHO covid-19 …

Context Theory and simulation suggest that randomized controlled trials (RCTs) stopped early
for benefit (truncated RCTs) systematically overestimate treatment effects for the outcome …

Objective To explore the extent to which components of composite end points in randomised
controlled trials vary in importance to patients, the frequency of events in the more and less …

Background: Conflicting reports exist in the medical literature regarding the association
between industry funding and published research findings. In this study, we examine the …

Importance Little is known about the relationship between perioperative high-sensitivity
troponin T (hsTnT) measurements and 30-day mortality and myocardial injury after noncardiac …

Background: Fluid resuscitation is the cornerstone of sepsis treatment. However, whether
balanced or unbalanced crystalloids or natural or synthetic colloids confer a survival …

Background: People with known risk factors for chronic obstructive pulmonary disease (COPD)
are important targets for screening and early intervention. We sought to measure the …

Objective To investigate the credibility of authors’ claims of subgroup effects using a representative
sample of recently published randomised controlled trials. Design Systematic review. …

Background The effects of thromboprophylaxis with low-molecular-weight heparin, as
compared with unfractionated heparin, on venous thromboembolism, bleeding, and other …

Objectives : We conducted a systematic review and meta-analysis to determine if pre-operative
brain natriuretic peptide (BNP) (ie, BNP or N-terminal pro–B-type natriuretic peptide [NT-…