Background Concerns regarding the safety of transfused blood have led to the development
of a range of interventions to minimise blood loss during major surgery. Anti‐fibrinolytic …

Background There is considerable uncertainty regarding the optimal haemoglobin threshold
for the use of red blood cell (RBC) transfusions in anaemic patients. Blood is a scarce …

A concerted effort to tackle the global health problem posed by traumatic brain injury (TBI) is
long overdue. TBI is a public health challenge of vast, but insufficiently recognised, …

Background Antifibrinolytic agents are commonly used during cardiac surgery to minimize
bleeding and to reduce exposure to blood products. We sought to determine whether …

Background Mesenchymal stromal cells (MSCs, “adult stem cells”) have been widely used
experimentally in a variety of clinical contexts. There is interest in using these cells in critical …

Background: Treatment of moderate or severe chronic obstructive pulmonary disease (COPD)
with combinations of inhaled corticosteroids, long-acting β-agonists, and long-acting …

Red cell (RBC) transfusions are a potentially life‐saving therapy employed during the care
of many critically ill patients to replace losses in hemoglobin to maintain oxygen delivery to …

Importance Hydroxyethyl starch is commonly used for volume resuscitation yet has been
associated with serious adverse events, including acute kidney injury and death. Clinical trials …

Background Concerns regarding the safety of transfused blood have prompted reconsideration
of the use of allogeneic (from an unrelated donor) red blood cell (RBC) transfusion, and …

The efficacy of convalescent plasma for coronavirus disease 2019 (COVID-19) is unclear.
Although most randomized controlled trials have shown negative results, uncontrolled studies …