Levels of inflammatory mediators in circulation are known to increase with age, but the
underlying cause of this age-associated inflammation is debated. We find that, when maintained …

The gut microbiota changes with age, but it is not clear to what degree these changes are
due to physiologic changes, age-associated inflammation or immunosenescence, diet, …

Background Exercise may help to mitigate symptoms of depression by reducing inflammation;
however, little is known about the influence of exercise intensity on depressed mood. …

Dendritic cells (DC) are instrumental in orchestrating an appropriately polarized Th cell
response to pathogens. DC exhibit considerable phenotypic and functional plasticity, influenced …

Highlights • One third of deaths in adults in the elderly are due to infectious disease. • Changes
in the aging immune response increase the risk of infection in the elderly. • Respiratory, …

Monocyte phenotype and output changes with age, but why this occurs and how it impacts
anti-bacterial immunity are not clear. We found that, in both humans and mice, circulating …

The role of LL-37, a human cationic antimicrobial peptide, in the immune system is not yet
clearly understood. It is a widely expressed peptide that can be up-regulated during an …

The sole human cathelicidin peptide, LL-37, has been demonstrated to protect animals against
endotoxemia/sepsis. Low, physiological concentrations of LL-37 (≤ 1 μg/ml) were able …

Host defense peptides (often called cationic antimicrobial peptides) have pleiotropic
immunomodulatory functions. The human host defense peptide LL-37 is up-regulated at sites of …

Host defence peptides are found in all classes of life and are a fundamental component of
the innate immune response. Initially it was believed that their sole role in innate immunity …