Genes and mechanisms involved in common complex diseases, such as the autoimmune
disorders that affect approximately 5% of the population, remain obscure. Here we identify …

Although abnormal glucose metabolism defines type 2 diabetes mellitus (T2DM) and accounts
for many of its symptoms and complications, efforts to understand the pathogenesis of …

Recent studies in murine models suggest that resistin (also called Fizz3 [ 1 ]), a novel
cysteine-rich protein secreted by adipocytes, may represent the long-sought link between obesity …

Among 141 consecutive patients with neuropsychiatric abnormalities due to cobalamin
deficiency, we found that 40 (28 percent) had no anemia or macrocytosis. The hematocrit was …

This review discusses the development and uses of imatinib mesylate, a protein tyrosine
kinase inhibitor useful in the treatment of chronic myelogenous leukemia and gastrointestinal …

Adipocyte complement-related protein of 30 kDa (Acrp30, adiponectin, or AdipoQ) is a fat-derived
secreted protein that circulates in plasma. Adipose tissue expression of Acrp30 is …

In this study we report convincing statistical support for a sixth type 1 diabetes (T1D) locus in
the innate immunity viral RNA receptor gene region IFIH1 (also known as mda-5 or Helicard…

The neurologic disorders associated with perni-cious anemia were well described in the
literature of the late nineteenth century and the first decades of this century (5, 17, 31, 54, 67, 89…

purpose: Patients with cobalamin (vitamin B12) deficiency usually lack many of the classic
features of severe megaloblastic anemia; because of the low diagnostic specificity of …

This treatise provides in-depth coverage of a specific area of process technology: removal
of acid gases from industrial gas mixtures. The coverage is divided into four parts. The first …