Heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors constitute
the largest family of eukaryotic signal transduction proteins that communicate across the …

G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to
hormones, neurotransmitters and environmental stimulants, and so have great potential as …

Structural analysis of G-protein-coupled receptors (GPCRs) for hormones and neurotransmitters
has been hindered by their low natural abundance, inherent structural flexibility, and …

G protein coupled receptors (GPCRs) exhibit a spectrum of functional behaviours in response
to natural and synthetic ligands. Recent crystal structures provide insights into inactive …

The β 2 -adrenergic receptor (β 2 AR) is a well-studied prototype for heterotrimeric guanine
nucleotide–binding protein (G protein)–coupled receptors (GPCRs) that respond to diffusible …

During 1984–1996, welfare and tax policy were changed to encourage work by single
mothers. The Earned Income Tax Credit was expanded, welfare benefits were cut, welfare time …

G-protein-coupled receptors (GPCRs) are eukaryotic integral membrane proteins that
modulate biological function by initiating cellular signalling in response to chemically diverse …

Acetylcholine, the first neurotransmitter to be identified 1 , exerts many of its physiological
actions via activation of a family of G-protein-coupled receptors (GPCRs) known as muscarinic …

Deep neural networks excel at function approximation, yet they are typically trained from
scratch for each new function. On the other hand, Bayesian methods, such as Gaussian …

Purpose: KRAS mutations are found in ∼25% of lung adenocarcinomas in Western countries
and, as a group, have been strongly associated with cigarette smoking. These mutations …