Several of the cancer immunotherapies under investigation or in clinical use target the
programmed death-ligand 1/programmed death-1 (PD-L1/PD-1) signaling axis. PD-L1 expression …

OBJECTIVE: Mutational activation of PIK3CA is associated with poor prognosis in patients
with solid tumors, and may predict favorable response to PI3K/AKT/mTOR pathway inhibitors. …

Purpose With the results of several recently published clinical trials, this guideline informs
on the use of adjuvant radiation therapy (RT) and systemic therapy in the treatment of …

Background Pathologic complete response (pCR) to neoadjuvant chemoradiation (CRT) for
rectal cancer is associated with better long-term outcomes, and is used as an early indicator …

Purpose: To evaluate the toxicity and effectiveness of celecoxib in combination with definitive
chemoradiotherapy (CRT) in women with locally advanced cervical cancer. Methods and …

Introduction Anemia has long been associated with poor prognosis in patients with cervical
cancer. Recently, additional hematologic parameters have emerged as potential indicators of …

The phosphatidylinositol-3 kinase (PI3K)/Akt/mTOR signaling pathway is activated in many
human cancers. Previously, we reported that patients with early stage cervical cancer whose …

Objective Cervical cancer is responsible for more than a quarter of a million deaths globally
each year, mostly in developing countries, making therapeutic advances in all health care …

Purpose This study aimed to describe the prognostic value of PI3K/AKT pathway mutations
in a large cohort of patients with cervical cancer. Experimental design Patients with pre-…

PURPOSE: To survey the current use and future plans for image-guided brachytherapy (BT)
for cervical cancer by radiation oncologists in Canada. METHODS AND MATERIALS: …