Neonatal sepsis in low-income countries: epidemiology, diagnosis and prevention

CR Popescu, MMM Cavanagh, B Tembo… - Expert review of anti …, 2020 - Taylor & Francis
Introduction: Sepsis accounts for up to one-third of neonatal deaths in the world each year.
The World Health Organization acknowledges neonatal sepsis as a major global health …

[HTML][HTML] Hyperoxia exposure impairs nephrogenesis in the neonatal rat: role of HIF-1α

CR Popescu, MR Sutherland, A Cloutier, G Benoît… - PloS one, 2013 - journals.plos.org
Preterm neonates are exposed at birth to high oxygen concentrations relative to the intrauterine
environment. We have previously shown in a rat model that a hyperoxic insult results in …

Rethinking management of neonates at risk of sepsis

PM Lavoie, CR Popescu, EM Molyneux, JL Wynn… - The Lancet, 2019 - thelancet.com
Comment 280 www. thelancet. com Vol 394 July 27, 2019 are often unavailable in these
settings, thus antibiotics can be started without measures to inform cessation of therapy. Non-…

DDIT4L regulates mitochondrial and innate immune activities in early life

…, C Cheung, JH Oh, E Ackermann, CR Popescu… - JCI …, 2024 - Am Soc Clin Investig
Pattern-Recognition Receptor responses are profoundly attenuated before the third
trimester of gestation, in the relatively low oxygen human fetal environment. However, the …

Verbal Autopsy to Assess Postdischarge Mortality in Children With Suspected Sepsis in Uganda

…, M Maina, R Carter, CR Popescu, R Daftary… - …, 2023 - publications.aap.org
BACKGROUND Reducing child mortality in low-income countries is constrained by a lack of
vital statistics. In the absence of such data, verbal autopsies provide an acceptable method …

[HTML][HTML] Whole blood genome-wide transcriptome profiling and metagenomics next-generation sequencing in young infants with suspected sepsis in a low-and middle …

CR Popescu, B Tembo, R Chifisi… - Gates Open …, 2020 - ncbi.nlm.nih.gov
Conducting collaborative and comprehensive epidemiological research on neonatal sepsis
in low-and middle-income countries (LMICs) is challenging due to a lack of diagnostic tests. …

[HTML][HTML] Piezoelectric Biocomposites for Bone Grafting in Dentistry

…, R Trusca, RC Popescu, I Raut, M Constantin… - Polymers, 2023 - mdpi.com
In this research, Hydroxyapatite—Potassium, Sodium Niobate—Chitosan (HA-KNN-CSL)
biocomposites were synthesized, both as hydrogel and ultra-porous scaffolds, to offer two …

[HTML][HTML] World Health Organization Danger Signs to predict bacterial sepsis in young infants: A pragmatic cohort study

O Akinseye, CR Popescu… - PLOS Global Public …, 2023 - journals.plos.org
Bacterial sepsis is generally a major concern in ill infants. To help triaging decisions by front-line
health workers in these situations, the World Health Organization (WHO) has …

Outcomes related to respiratory syncytial virus with an abbreviated palivizumab regimen in children with congenital heart disease: a descriptive analysis

J Claydon, CR Popescu, L Shaiba… - … Open Access Journal, 2019 - cmajopen.ca
Background: It has been hypothesized that 4 doses of palivizumab, a neutralizing monoclonal
antibody against respiratory syncytial virus (RSV), administered during a fixed-date RSV …

World Health Organization Danger Signs to predict bacterial sepsis in newborns: A pragmatic prospective cohort study

O Akinseye, CR Popescu, M Chiume-Kayuni, MA Irvine… - medRxiv, 2023 - medrxiv.org
Background The World Health Organization (WHO) has developed danger signs (DS) to
help front-line health workers triage interventions in children with severe illnesses. Our …