Background: The annual cut-off date of birth for entry to school in British Columbia, Canada,
is Dec. 31. Thus, children born in December are typically the youngest in their grade. We …

Objectives: Most contemporary epidemiologic studies require complex analytical methods
to adjust for bias and confounding. New methods are constantly being developed, and older …

Objective To quantify an association between acute kidney injury and use of high potency
statins versus low potency statins. Design Retrospective observational analysis of …

Background— Bias in studies of preventive medications can occur when healthier patients
are more likely to initiate and adhere to therapy than less healthy patients. We sought …

Background There is concern that antidiabetic incretin-based drugs, including dipeptidyl
peptidase 4 (DPP-4) inhibitors and glucagon-like peptide 1 (GLP-1) analogues, can increase …

Objective Previous observational studies suggest that the use of proton pump inhibitors (PPIs)
may increase the risk of hospitalisation for community-acquired pneumonia (HCAP). …

Objective To evaluate the incremental increase in new onset diabetes from higher potency
statins compared with lower potency statins when used for secondary prevention. Design …

Purpose The role of administrative databases for research on drug safety during pregnancy
can be limited by their inaccurate assessment of the timing of exposure, as the gestational …

Abstract Although administrative health care databases have long been used to evaluate
adverse drug effects, responses to drug safety signals have been slow and uncoordinated. We …

Background Clinical trials and meta-analyses have found that rosiglitazone maleate, a
thiazolidinedione that is prescribed for type 2 diabetes mellitus, increases the risk of fractures in …