Therapy development for adult diffuse glioma is hindered by incomplete knowledge of somatic
glioma driving alterations and suboptimal disease classification. We defined the complete …

Embryonal tumours of the central nervous system (CNS) represent a heterogeneous group
of tumours about which little is known biologically, and whose diagnosis, on the basis of …

Purpose: Genomic profiling studies suggest that triple-negative breast cancer (TNBC) is a
heterogeneous disease. In this study, we sought to define TNBC subtypes and identify subtype…

Medulloblastoma is a malignant childhood brain tumour comprising four discrete subgroups.
Here, to identify mutations that drive medulloblastoma, we sequenced the entire genomes …

Background Evidence suggests that physiologic pacing (dual-chamber or atrial) may be
superior to single-chamber (ventricular) pacing because it is associated with lower risks of atrial …

Background Current treatment for medulloblastoma, which includes postoperative radiotherapy
and 1 year of chemotherapy, does not cure many children with high-risk disease. We …

Purpose Traditional genetic approaches to identify gene mutations in cancer are expensive
and laborious. Nonetheless, if we are to avoid rejecting effective molecular targeted …

Purpose Medulloblastomas are heterogeneous tumors that collectively represent the most
common malignant brain tumor in children. To understand the molecular characteristics …

To identify risk variants for glioma, we conducted a meta-analysis of two genome-wide
association studies by genotyping 550K tagging SNPs in a total of 1,878 cases and 3,670 controls…

Abstract Analysis of molecular aberrations across multiple cancer types, known as pan-cancer
analysis, identifies commonalities and differences in key biological processes that are …