Importance Growing interest in microbial dysbiosis during critical illness has raised
questions about the therapeutic potential of microbiome modification with probiotics. Prior …

Background: Clinical data on patients admitted to hospital with coronavirus disease 2019 (COVID-19)
provide clinicians and public health officials with information to guide practice and …

Background Veno‐venous extracorporeal membrane oxygenation (V‐V ECMO) is a lifesaving
support modality for severe respiratory failure, but its resource‐intensive nature led to …

Background Individuals vaccinated against severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2), when infected, can still develop disease that requires hospitalization. It …

Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)
and Meta-Analysis of Observational Studies in Epidemiology (MOOSE) standards were …

We examined the effect of an antimicrobial stewardship program (ASP), procalcitonin
testing and rapid blood-culture identification on hospital mortality in a prospective quality …

Objectives: Use systematic review and meta-analytic methodology to estimate the pooled
incidence, prevalence, and proportion of delirium cases for each delirium subtype (hypoactive, …

1. McNicholas BA, Rezoagli E, Simpkin AJ, et al. Epidemiology and outcomes of early-onset
AKI in COVID-19-related ARDS in comparison with non-COVID-19-related ARDS: insights …

… Patricia Lemieux for constructive presubmission feedback on this manuscript, and
Sharon Venantius and Cassidy Codan for assistance with manuscript preparation. …

Background Using a large dataset, we evaluated prevalence and severity of alterations in
liver enzymes in COVID-19 and association with patient-centred outcomes. Methods We …