Importance Scalable deprescribing interventions may reduce polypharmacy and the use of
potentially inappropriate medications (PIMs); however, few studies have been large enough …

Background: Clinical data on patients admitted to hospital with coronavirus disease 2019 (COVID-19)
provide clinicians and public health officials with information to guide practice and …

The International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) is
a global federation of clinical research networks that work collaboratively to prevent illness …

Introduction Acute kidney injury (AKI) has been identified as one of the most common and
significant problems in hospitalized patients with COVID-19. However, studies examining the …

Background Veno‐venous extracorporeal membrane oxygenation (V‐V ECMO) is a lifesaving
support modality for severe respiratory failure, but its resource‐intensive nature led to …

Importance Research diversity and representativeness are paramount in building trust,
generating valid biomedical knowledge, and possibly in implementing clinical guidelines. …

Background Individuals vaccinated against severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2), when infected, can still develop disease that requires hospitalization. It …

OBJECTIVES Polypharmacy is common in older adults and associated with adverse drug
events (ADEs). Several methods have been described in studies to help correlate ADE …

Background COVID-19 has been associated with a broad range of thromboembolic, ischemic,
and hemorrhagic complications (coagulopathy complications). Most studies have focused …

Background The impact of the COVID-19 pandemic on paediatric populations varied between
high-income countries (HICs) versus low-income to middle-income countries (LMICs). We …