BACKGROUND: The availability of genetic testing for inherited mutations in the BRCA1 gene
provides potentially valuable information to women at high risk of breast or ovarian cancer; …

… Olopade, Andrea Eisen, Barbara Weber, Jane McLennan, Ping Sun, William D. Foulkes,
and Steven A. Narod … Rebbeck TR, Levin AM, Eisen A, et al: Reduction in breast cancer …

Purpose The purposes of this study were to estimate the reduction in risk of ovarian, fallopian
tube, or peritoneal cancer in women with a BRCA1 or BRCA2 mutation after oophorectomy…

Background: A sensitive and acceptable screening regimen for women at high risk for breast
cancer is essential. Contrast-enhanced magnetic resonance imaging (MRI) of the breast is …

Purpose The purpose of this study was to estimate the extent of protection offered against
breast cancer by prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations and to …

Purpose Bilateral prophylactic oophorectomy (BPO) is widely used for cancer risk reduction
in women with BRCA1/2 mutations. Many premenopausal women choose to take hormone …

Each year in the United States, breast cancer is diagnosed in more than 170,000 women.
Despite this substantial burden of disease, however, assessment of breast-cancer risk has …

Background The randomized, double-blind OlympiA trial compared 1 year of the oral poly(adenosine
diphosphate-ribose) polymerase inhibitor, olaparib, to matching placebo as …

Purpose An accurate evaluation of the penetrance of BRCA1 and BRCA2 mutations is
essential to the identification and clinical management of families at high risk of breast and …

… Olivotto, Andrea Eisen, Timothy J. Whelan, Olufunmilayo I. Olopade, Claudine Isaacs, Sofia
D. … Rebbeck T, Levin A, Eisen A, et al: Breast cancer risk after bilateral prophylactic …