Inflammation plays a critical role in host defense, maintaining cellular and tissue integrity
following chemical, physical and biological insults. Inflammation presents in a variety of acute …

Background Physicians face competing demands of maximizing pathogen coverage while
minimizing unnecessary use of broad-spectrum antibiotics when managing sepsis. We …

Drug efflux transporters in the placenta can significantly influence the materno-fetal transfer
of a diverse array of drugs and other xenobiotics. To determine if clinically important drug …

… Author links open overlay panel Alex M. Cressman MSc a b , Erin M. Macdonald MSc a ,
Zhan Yao MS a , Peter C. Austin PhD a c , Tara Gomes MHSc a c d e , John Michael Paterson …

… Author links open overlay panel Alex M. Cressman MSc 1 2 , Aniket Natekar MSc 1 , Eunji Kim
MHSc 1 , Gideon Koren MD FRCPC, FACMT 1 2 , Pina … Gause, AL Raymundo, M. Stevens …

Question Despite being highly motivated to quit, many of my patients struggle with smoking
cessation during pregnancy. Can you comment on the current treatment options and discuss …

Background: Naloxone is life-saving when administered after opioid overdose. In March 2016,
the Canadian government made the antidote available without prescription, but anecdotal …

Small studies suggest that prescription stimulants can precipitate psychosis and mania. We
conducted a population-based case-crossover study to examine whether hospitalization for …

Question In my practice several patients have struggled with cocaine abuse during their
pregnancies. One woman, now postpartum, wants to breastfeed her infant. Despite being …

Preventing and treating malaria in pregnancy is a global health priority. However little is
known regarding the impact of malaria infection on the maternal and fetal disposition of …