User profiles for Akram Alyass

Akram Alyass

McMaster University
Verified email at mcmaster.ca
Cited by 1656

From big data analysis to personalized medicine for all: challenges and opportunities

A Alyass, M Turcotte, D Meyre - BMC medical genomics, 2015 - Springer
Recent advances in high-throughput technologies have led to the emergence of systems
biology as a holistic science to achieve more precise modeling of complex diseases. Many …

Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

…, MH Zafarmand, B Heude, IS Farooqi, A Alyass… - PLoS …, 2020 - journals.plos.org
The genetic background of childhood body mass index (BMI), and the extent to which the
well-known associations of childhood BMI with adult diseases are explained by shared genetic …

Modelling of OGTT curve identifies 1 h plasma glucose level as a strong predictor of incident type 2 diabetes: results from two prospective cohorts

A Alyass, P Almgren, M Akerlund, J Dushoff, B Isomaa… - Diabetologia, 2015 - Springer
Aims/hypothesis The relevance of the OGTT in predicting type 2 diabetes is unclear. We
assessed the performance of 14 OGTT glucose traits in type 2 diabetes prediction. Methods We …

A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity

…, L Fernandez-Rhodes, A Alyass… - Human molecular …, 2019 - academic.oup.com
Although hundreds of genome-wide association studies-implicated loci have been reported
for adult obesity-related traits, less is known about the genetics specific for early-onset …

[PDF][PDF] Penetrance of polygenic obesity susceptibility loci across the body mass index distribution

A Abadi, A Alyass, SR du Pont, B Bolker… - The American Journal of …, 2017 - cell.com
A growing number of single-nucleotide polymorphisms (SNPs) have been associated with
body mass index (BMI) and obesity, but whether the effects of these obesity-susceptibility loci …

[HTML][HTML] Global prevalence of burnout among postgraduate medical trainees: a systematic review and meta-regression

…, B Dennis, O Kavanagh, L Banfield, A Alyass… - … Open Access Journal, 2021 - cmajopen.ca
Background: Burnout among postgraduate medical trainees (PMTs) is increasingly being
recognized as a crisis in the medical profession. We aimed to establish the prevalence of …

Prognostic significance of cytoplasmic S100A2 overexpression in oral cancer patients

M Kumar, G Srivastava, J Kaur, J Assi, A Alyass… - Journal of translational …, 2015 - Springer
Background Oral squamous cell carcinoma (OSCC) patients are at high risk of loco-regional
recurrence and 5-year survival rates are about 50%. Identification of patients at high risk of …

A systematic survey of the methods literature on the reporting quality and optimal methods of handling participants with missing outcome data for continuous outcomes …

Y Zhang, A Alyass, T Vanniyasingam… - Journal of clinical …, 2017 - Elsevier
Objective To conduct (1) a systematic survey of the reporting quality of simulation studies
dealing with how to handle missing participant data (MPD) in randomized control trials and (2) …

Validity of self-report of cardiovascular risk factors in a population at high risk for stroke

AK Dey, A Alyass, RT Muir, SE Black, RH Swartz… - Journal of Stroke and …, 2015 - Elsevier
Background Screening for vascular risk factors is commonly assessed through self-report,
despite reports of low sensitivity using this approach in healthy populations. The validity of self-…

Association between PPAR-γ2 Pro12Ala genotype and insulin resistance is modified by circulating lipids in Mexican children

C Stryjecki, J Peralta-Romero, A Alyass… - Scientific reports, 2016 - nature.com
The Pro12Ala (rs1801282) polymorphism in peroxisome proliferator-activated receptor-γ2 (PPAR-γ2)
has been convincingly associated with insulin resistance (IR) and type 2 diabetes (…