User profiles for Akram Alyass
Akram AlyassMcMaster University Verified email at mcmaster.ca Cited by 1656 |
From big data analysis to personalized medicine for all: challenges and opportunities
Recent advances in high-throughput technologies have led to the emergence of systems
biology as a holistic science to achieve more precise modeling of complex diseases. Many …
biology as a holistic science to achieve more precise modeling of complex diseases. Many …
Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
The genetic background of childhood body mass index (BMI), and the extent to which the
well-known associations of childhood BMI with adult diseases are explained by shared genetic …
well-known associations of childhood BMI with adult diseases are explained by shared genetic …
Modelling of OGTT curve identifies 1 h plasma glucose level as a strong predictor of incident type 2 diabetes: results from two prospective cohorts
Aims/hypothesis The relevance of the OGTT in predicting type 2 diabetes is unclear. We
assessed the performance of 14 OGTT glucose traits in type 2 diabetes prediction. Methods We …
assessed the performance of 14 OGTT glucose traits in type 2 diabetes prediction. Methods We …
A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity
…, L Fernandez-Rhodes, A Alyass… - Human molecular …, 2019 - academic.oup.com
Although hundreds of genome-wide association studies-implicated loci have been reported
for adult obesity-related traits, less is known about the genetics specific for early-onset …
for adult obesity-related traits, less is known about the genetics specific for early-onset …
[PDF][PDF] Penetrance of polygenic obesity susceptibility loci across the body mass index distribution
A growing number of single-nucleotide polymorphisms (SNPs) have been associated with
body mass index (BMI) and obesity, but whether the effects of these obesity-susceptibility loci …
body mass index (BMI) and obesity, but whether the effects of these obesity-susceptibility loci …
[HTML][HTML] Global prevalence of burnout among postgraduate medical trainees: a systematic review and meta-regression
Background: Burnout among postgraduate medical trainees (PMTs) is increasingly being
recognized as a crisis in the medical profession. We aimed to establish the prevalence of …
recognized as a crisis in the medical profession. We aimed to establish the prevalence of …
Prognostic significance of cytoplasmic S100A2 overexpression in oral cancer patients
Background Oral squamous cell carcinoma (OSCC) patients are at high risk of loco-regional
recurrence and 5-year survival rates are about 50%. Identification of patients at high risk of …
recurrence and 5-year survival rates are about 50%. Identification of patients at high risk of …
A systematic survey of the methods literature on the reporting quality and optimal methods of handling participants with missing outcome data for continuous outcomes …
Objective To conduct (1) a systematic survey of the reporting quality of simulation studies
dealing with how to handle missing participant data (MPD) in randomized control trials and (2) …
dealing with how to handle missing participant data (MPD) in randomized control trials and (2) …
Validity of self-report of cardiovascular risk factors in a population at high risk for stroke
Background Screening for vascular risk factors is commonly assessed through self-report,
despite reports of low sensitivity using this approach in healthy populations. The validity of self-…
despite reports of low sensitivity using this approach in healthy populations. The validity of self-…
Association between PPAR-γ2 Pro12Ala genotype and insulin resistance is modified by circulating lipids in Mexican children
C Stryjecki, J Peralta-Romero, A Alyass… - Scientific reports, 2016 - nature.com
The Pro12Ala (rs1801282) polymorphism in peroxisome proliferator-activated receptor-γ2 (PPAR-γ2)
has been convincingly associated with insulin resistance (IR) and type 2 diabetes (…
has been convincingly associated with insulin resistance (IR) and type 2 diabetes (…