Ongoing efforts to improve survival, and enhance quality of life have led biomedical research
to focus on disease and the mechanisms that increase risk for disease. The other side of …

Increasing age and carrying an APOEε4 allele are well established risk factors for Alzheimer's
disease (AD). The earlier age of onset of AD observed in ε4-carriers may reflect an …

There is a well-established association between APOE genotype and the risk of developing
Alzheimer's disease (AD). Relative to individuals with the common ε3/ε3 genotype, carriers …

Important risk factors for Alzheimer's disease (AD) are ageing and the Apolipoprotein E (APOE)
ε4 allele, with female APOE ε4 carriers having the greatest risk. In this study we …

In the last decade, functional magnetic resonance imaging (fMRI) has emerged as a tool to
study changes in brain function associated with a genetic risk for Alzheimer's disease (AD), …

BACKGROUND: The legalization of medical assistance in dying will affect health care
spending in Canada. Our aim was to determine the potential costs and savings associated with …

Resting-state fMRI (R-fMRI) has shown considerable promise in providing potential biomarkers
for diagnosis, prognosis and drug response across a range of diseases. Incorporating R-…

PURPOSE Individuals of lower socioeconomic status have higher rates of hospitalization
due to ambulatory care–sensitive conditions, particularly chronic obstructive pulmonary …

Possession of the APOE-ε4 allele is the best established genetic risk factor for sporadic
Alzheimer's disease (AD), while the ε2 allele may confer protection against the disease. Previous …

Uremic pruritus remains a top research priority. Patients with uremic pruritus may be able to
look forward to a new decade of understanding, knowledge, and novel treatment options for …