User profiles for Zhan Yao
Zhan YaoLoxo oncology at Lilly Verified email at loxooncology.com Cited by 4392 |
[PDF][PDF] BRAF mutants evade ERK-dependent feedback by different mechanisms that determine their sensitivity to pharmacologic inhibition
ERK signaling requires RAS-induced RAF dimerization and is limited by feedback. Activated
BRAF mutants evade feedback inhibition of RAS by either of two mechanisms. BRAF V600 …
BRAF mutants evade feedback inhibition of RAS by either of two mechanisms. BRAF V600 …
Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS
Approximately 200 BRAF mutant alleles have been identified in human tumours. Activating
BRAF mutants cause feedback inhibition of GTP-bound RAS, are RAS-independent and …
BRAF mutants cause feedback inhibition of GTP-bound RAS, are RAS-independent and …
Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor
Precision medicines exert selective pressure on tumour cells that leads to the preferential
growth of resistant subpopulations, necessitating the development of next-generation …
growth of resistant subpopulations, necessitating the development of next-generation …
TGF-β IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer
Z Yao, S Fenoglio, DC Gao… - Proceedings of the …, 2010 - National Acad Sciences
The epidermal growth-factor receptor (EGFR) tyrosine kinase inhibitor erlotinib has been
proven to be highly effective in the treatment of nonsmall cell lung cancer (NSCLC) harboring …
proven to be highly effective in the treatment of nonsmall cell lung cancer (NSCLC) harboring …
Diverse and targetable kinase alterations drive histiocytic neoplasms
EL Diamond, BH Durham, J Haroche, Z Yao, J Ma… - Cancer discovery, 2016 - AACR
Histiocytic neoplasms are clonal, hematopoietic disorders characterized by an accumulation
of abnormal, monocyte-derived dendritic cells or macrophages in Langerhans cell …
of abnormal, monocyte-derived dendritic cells or macrophages in Langerhans cell …
Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence
…, H Won, C Liu, S Tiwari, L Kong, AJ Hanrahan, Z Yao… - Cancer research, 2014 - AACR
Melanoma is a disease characterized by lesions that activate ERK. Although 70% of cutaneous
melanomas harbor activating mutations in the BRAF and NRAS genes, the alterations …
melanomas harbor activating mutations in the BRAF and NRAS genes, the alterations …
Smoking, drinking, diet and physical activity—modifiable lifestyle risk factors and their associations with age to first chronic disease
R Ng, R Sutradhar, Z Yao, WP Wodchis… - International journal …, 2020 - academic.oup.com
Background This study examined the incidence of a person’s first diagnosis of a selected
chronic disease, and the relationships between modifiable lifestyle risk factors and age to first …
chronic disease, and the relationships between modifiable lifestyle risk factors and age to first …
Expression signatures of exosomal long non-coding RNAs in urine serve as novel non-invasive biomarkers for diagnosis and recurrence prediction of bladder cancer
Y Zhan, L Du, L Wang, X Jiang, S Zhang, J Li, K Yan… - Molecular Cancer, 2018 - Springer
Recently, expression signatures of exosomal long non-coding RNAs (lncRNAs) have been
proposed as potential non-invasive biomarkers for cancer detection. In this study, we aimed …
proposed as potential non-invasive biomarkers for cancer detection. In this study, we aimed …
ZAIGA: Zhaoshan long-baseline atom interferometer gravitation antenna
MS Zhan, J Wang, WT Ni, DF Gao, G Wang… - … Journal of Modern …, 2020 - World Scientific
The Zhaoshan long-baseline Atom Interferometer Gravitation Antenna (ZAIGA) is a new type
of underground laser-linked interferometer facility, and is currently under construction. It is …
of underground laser-linked interferometer facility, and is currently under construction. It is …
Rapid induction of apoptosis by PI3K inhibitors is dependent upon their transient inhibition of RAS–ERK signaling
M Will, ACR Qin, W Toy, Z Yao, V Rodrik-Outmezguine… - Cancer discovery, 2014 - AACR
The effects of selective phosphoinositide 3-kinase (PI3K) and AKT inhibitors were compared
in human tumor cell lines in which the pathway is dysregulated. Both caused inhibition of …
in human tumor cell lines in which the pathway is dysregulated. Both caused inhibition of …