Pathophysiology of the brain extracellular matrix: a new target for remyelination
…, R Cua, MB Keough, S Haylock-Jacobs… - Nature Reviews …, 2013 - nature.com
The extracellular matrix (ECM) occupies a notable proportion of the CNS and contributes to
its normal physiology. Alterations to the ECM occur after neural injury (for example, in …
its normal physiology. Alterations to the ECM occur after neural injury (for example, in …
Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination
LW Lau, MB Keough, S Haylock‐Jacobs… - Annals of …, 2012 - Wiley Online Library
Objective: Failure of remyelination is a critical impediment to recovery in multiple sclerosis (MS).
Chondroitin sulfate proteoglycans (CSPGs) have been reported to accumulate in MS …
Chondroitin sulfate proteoglycans (CSPGs) have been reported to accumulate in MS …
Inhibition of CCR6 function reduces the severity of experimental autoimmune encephalomyelitis via effects on the priming phase of the immune response
…, RE Kohler, S Townley, S Haylock-Jacobs… - The Journal of …, 2009 - journals.aai.org
Chemokines are essential for homeostasis and activation of the immune system. The chemokine
ligand/receptor pairing CCL20/CCR6 is interesting because these molecules display …
ligand/receptor pairing CCL20/CCR6 is interesting because these molecules display …
An immune paradox: how can the same chemokine axis regulate both immune tolerance and activation? CCR6/CCL20: a chemokine axis balancing immunological …
Chemokines (chemotactic cytokines) drive and direct leukocyte traffic. New evidence
suggests that the unusual CCR6/CCL20 chemokine receptor/ligand axis provides key homing …
suggests that the unusual CCR6/CCL20 chemokine receptor/ligand axis provides key homing …
PI3Kδ drives the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting effector T cell apoptosis and promoting Th17 differentiation
S Haylock-Jacobs, I Comerford, M Bunting, E Kara… - Journal of …, 2011 - Elsevier
The Class IA phosphoinositide 3-kinase delta (PI3Kδ) has been implicated in multiple
signaling pathways involved in leukocyte activation and hence is an attractive target in many …
signaling pathways involved in leukocyte activation and hence is an attractive target in many …
Antagonism of the chemokine receptors CXCR3 and CXCR4 reduces the pathology of experimental autoimmune encephalomyelitis
…, I Comerford, S Townley, S Haylock‐Jacobs… - Brain …, 2008 - Wiley Online Library
Chemokines regulate lymphocyte trafficking under physiologic and pathologic conditions. In
this study, we have investigated the role of CXCR3 and CXCR4 in the activation of T …
this study, we have investigated the role of CXCR3 and CXCR4 in the activation of T …
The atypical chemokine receptor CCX-CKR scavenges homeostatic chemokines in circulation and tissues and suppresses Th17 responses
…, Y Harata-Lee, S Haylock-Jacobs… - Blood, The Journal …, 2010 - ashpublications.org
Our previous in vitro studies led to proposals that the atypical chemokine receptor CCX-CKR
is a scavenger of CCR7 ligand homeostatic chemokines. In the present study, we …
is a scavenger of CCR7 ligand homeostatic chemokines. In the present study, we …
Chondroitin sulphate proteoglycans: extracellular matrix proteins that regulate immunity of the central nervous system
The extracellular matrix (ECM) is a complex network of scaffolding molecules that also plays
an important role in cell signalling, migration and tissue structure. In the central nervous …
an important role in cell signalling, migration and tissue structure. In the central nervous …
[HTML][HTML] Molecular epidemiology and clinical characteristics of hepatitis D virus infection in Canada
C Osiowy, K Swidinsky, S Haylock-Jacobs, MD Sadler… - JHEP Reports, 2022 - Elsevier
Background & Aims HDV affects 4.5–13% of chronic hepatitis B (CHB) patients globally, yet
the prevalence of HDV infection in Canada is unknown. To investigate the prevalence, …
the prevalence of HDV infection in Canada is unknown. To investigate the prevalence, …
Effectiveness and renal safety of tenofovir alafenamide fumarate among chronic hepatitis B patients: real‐world study
…, M Brahmania, S Haylock‐Jacobs… - Journal of Viral …, 2021 - Wiley Online Library
Tenofovir alafenamide fumarate (TAF) has high plasma stability resulting in fewer renal
adverse events compared to tenofovir disoproxil fumarate (TDF) in chronic hepatitis B (CHB) …
adverse events compared to tenofovir disoproxil fumarate (TDF) in chronic hepatitis B (CHB) …