Importance The appropriate treatment target for systolic blood pressure (SBP) in older
patients with hypertension remains uncertain. Objective To evaluate the effects of intensive (<120 …

Importance There are currently no proven treatments to reduce the risk of mild cognitive
impairment and dementia. Objective To evaluate the effect of intensive blood pressure control on …

… Nicholas Pajewski had full access to all of the study data and takes responsibility for the
integrity of the data and the accuracy of the data analysis. Raj Padwal and Nicholas Pajewski …

Importance The effect of intensive blood pressure lowering on brain health remains uncertain.
Objective To evaluate the association of intensive blood pressure treatment with cerebral …

Despite rapid advances in genomic technology, our ability to account for phenotypic variation
using genetic information remains limited for many traits. This has unfortunately resulted in …

Objective: To determine the prevalence of the female athlete triad (low energy availability,
menstrual dysfunction, and low bone mineral density) in high school varsity athletes in a …

In spite of the well-known clustering of multiple autoimmune disorders in families, analyses
of specific shared genes and polymorphisms between systemic lupus erythematosus (SLE) …

The effect of clinic-based intensive hypertension treatment on ambulatory blood pressure (BP)
is unknown. The goal of the SPRINT (Systolic Blood Pressure Intervention Trial) …

Background The previously published results of the Systolic Blood Pressure Intervention Trial
showed that among participants with hypertension and an increased cardiovascular risk, …

Background: The Systolic Blood Pressure Intervention Trial (SPRINT) is testing whether a
lower systolic blood pressure (BP) target of 120mm Hg leads to a reduction in cardiovascular …