Summary of findings, high WPRS compared with low WPRS in mortality
| Patient or population: Mortality Setting: Emergency departments Intervention: High WPRS Comparison: Low WPRS | |||||
|---|---|---|---|---|---|
| Outcome | Anticipated absolute effect* (95% CI) | Relative effect (95% CI) | No. of participants | Certainty of the evidence (GRADE)† | |
| Risk with low WPRS | Risk with high WPRS | ||||
| Mortality | 1000 per 1000 | 450 per 1000 (260–780) | RR 0.45 (0.26–0.78) | 480 558 | ⊕⊕øø‡ Low§,¶,**,†† |
Note: CI = confidence interval; GRADE = Grading of Recommendations Assessment, Development and Evaluation; RR = risk ratio; WPRS = weighted pediatric readiness score.
↵* The risk in the intervention group (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
↵† GRADE Working Group grades of evidence. High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect.
↵‡ Commonly used symbols to describe certainty in evidence in evidence profiles: high certainty ⊕⊕⊕⊕, moderate certainty ⊕⊕⊕ø, low certainty ⊕⊕øø and very low certainty ⊕øøø.
↵§ We downgraded by 1 level for risk of bias. The contributing studies were all high.
↵¶ We downgraded by 1 level for inconsistency. There was considerable heterogeneity (I2 = 89%) and variation in point estimates.
↵** We upgraded by 1 level for large effect. The pooled odds ratio was less than 0.5.
↵†† We upgraded by 1 level for dose response gradient. We observed a change in odds ratio for every increase in WPRS.