Multivariable associations between patient-level factors for patients with 1 or more repeat adverse drug events compared with patients without any repeat events (n = 1178)
| Independent variable | Total no. of patients | No. (%) of patients with repeat events | Unadjusted OR (95% CI) | Adjusted OR* (95% CI) |
|---|---|---|---|---|
| Age | – | – | 1.00 (0.99–1.00) | 1.00 (0.99–1.01) |
| Sex | ||||
| Female | 662 | 215 (32.5) | 0.86 (0.70–1.05) | 0.89 (0.69–1.14) |
| Male | 516 | 185 (35.9) | 1.00 | 1.00 |
| Morbidities | ||||
| Diabetes | 247 | 99 (40.1) | 1.40 (1.00–1.96) | 1.35 (0.99–1.85) |
| Chronic heart failure | 134 | 46 (34.3) | 1.02 (0.86–1.22) | 0.92 (0.59–1.44) |
| Atrial fibrillation | 243 | 75 (30.9) | 0.84 (0.66–1.06) | 0.87 (0.60–1.26) |
| Renal failure | 118 | 57 (48.3) | 1.95 (1.52–2.51) | 2.01 (1.32–3.07) |
| Dementia | 75 | 27 (36.0) | 1.10 (0.42–2.88) | 1.11 (0.66–1.85) |
| Hypertension | 532 | 175 (32.9) | 0.92 (0.87–0.97) | 0.91 (0.67–1.23) |
| Mental health diagnosis | 230 | 93 (40.4) | 1.41 (0.77–2.62) | 1.39 (1.02–1.88) |
Note: CI = confidence interval, OR = odds ratio.
↵* Adjusted for age, sex, morbidities and clustering by hospital site.