| Characteristic | Cause of brain death | ||
|---|---|---|---|
| Anoxic brain injury (n = 100) | Traumatic brain injury (n = 51) | Stroke* (n = 63) | |
| Age, median (IQR), yr | 35 (23-52) | 25 (20-42)† | 53 (39-59)† |
| Sex, no. (%) | |||
| Female | 47 (47) | 20 (39) | 32 (51) |
| Male | 53 (53) | 31 (61) | 31 (49) |
| Body mass index, median (IQR) | 35 (25-47) | 30 (25-35) | 34 (24-43) |
| No. (%) who were expanded-criteria donors‡ | 12 (12)§ | 6 (12)§ | 24 (38) |
| No. (%) with positive result on viral serological testing (HIV, hepatitis B or C) | 6 (6) | 3 (6) | 6 (10) |
| No. of organs transplanted | |||
| Median (IQR) | 4 (2.5-5) | 4 (3-6)† | 5 (3-6)† |
| Mean ± standard deviation | 3.6 ± 1.9 | 4.5 ± 1.8† | 4.5 ± 2.2† |
| Kidney | |||
| Creatinine level, median (IQR), µmol/L | 86 (64-140) | 75 (52-96)† | 66 (50-83)† |
| Urea level, median (IQR), mmol/L | 6.6 (4.8-9.9) | 4.8 (3.6-6.3)† | 4.2 (3.2-7.3) |
| Urine output, median (IQR), mL/h | 65 (30-125) | 125 (63-200)† | 100 (45-175)† |
| 1 or 2 kidneys transplanted, no. (%) of donors | 84 (84) | 49 (96) | 53 (84) |
| Liver | |||
| Alanine aminotransferase level, median (IQR), units/L | 107 (59-283) | 34 (21-54)† | 23 (14-42)† |
| International normalized ratio, median (IQR) | 1.3 (1.2-1.4) | 1.2 (1.1-1.3) | 1.2 (1.1-1.3)† |
| Bilirubin level, median (IQR), µmol/L | 8 (5-13) | 10 (7-16) | 8 (6-12) |
| Transplanted, no. (%) of donors | 81 (81) | 47 (92) | 54 (86) |
| Lung | |||
| PaO2/FIO2 (last O2 challenge), median (IQR) | 251 (120-370) | 328 (218-407)† | 316 (227-394)† |
| 1 or 2 lungs transplanted, no. (%) of donors | 22 (22) | 21 (41)¶ | 34 (54)¶ |
| Heart | |||
| Troponin T level, median (IQR), ng/mL (low-sensitivity assay, before 2011)** | 0.30 (0.04-0.83) | 0.15 (0.03-0.40)† | 0.07 (0.03-0.32)† |
| Troponin T level, median (IQR), ng/L (high-sensitivity assay, as of 2011)** | 311 (65-1121) | 33 (9-62) | 14 (5-116) |
| Ejection fraction, median (IQR), %** | 55 (40-60) | 54 (40-60) | 60 (54-64) |
| Transplanted, no. (%) of donors | 30 (30) | 19 (37) | 23 (36) |
| Pancreas | |||
| Whole transplanted, no. (%) of donors | 20 (20) | 17 (33) | 14 (22) |
| Islet cells transplanted, no. (%) of donors | 20 (20) | 6 (12) | 20 (32) |
Note: IQR = interquartile range.
*Defined as subarachnoid hemorrhage, intracerebral hemorrhage or ischemic stroke.
†p < 0.05 compared with anoxic brain injury, analysis of variance with adjustment for multiple comparisons.
‡Defined as age 60 years or more, or age 50 years or more with at least 2 of hypertension, creatinine level greater than 132 µmol/L or death due to cerebrovascular accident.
§p < 0.05 compared with stroke, χ2 analysis.
¶p < 0.05 compared with anoxic brain injury, χ2 analysis.
**Troponin T and ejection fraction were available for 88% and 66% of donors, respectively. Other laboratory test results were available for 96%-99% of donors.