| Study | Sex | Mean age, yr | No. of participants* | Type of intervention for prior weight loss | Intervention type | Control | Intervention length, mo. | Location | Publication date |
|---|---|---|---|---|---|---|---|---|---|
| Champagne et al. (17) Svetkey et al. (18) | M + F | 55 | 1032 | Six-month diet plus group-based support | Lifestyle (delivery strategies: Internet or personal contact) | Self-directed | 30 | US | 2011 |
| Davidson et al. (12) | M + F | 43 | 306 | 120 mg orlistat 3×/d for 1 yr plus controlled-energy diet | 120 mg orlistat 3×/d plus weight-maintenance diet | Placebo plus same weight-maintenance diet | 12 | US | 1999 |
| Hauptman et al. (13) | M + F | 42 | 273 | 120 mg orlistat 3×/d for 1 yr plus energy-reduced diet | 120 mg orlistat 3×/d plus weight-maintenance diet | Placebo plus same weight-maintenance diet | 12 | US | 2000 |
| Hill et al. (14) | M + F | 46 | 369 | Six-month hypoenergetic diet plus encouraged to exercise | 120 mg orlistat 3×/d plus dietary and behavioural counselling | Placebo plus same diet and behavioural components | 12 | US | 1999 |
| Richelsen et al. (15) | M + F | 47 | 309 | Eight-week very low-energy diet | 120 mg orlistat 3×/d plus energy-restricted diet and dietary and lifestyle counselling | Placebo plus same diet and behavioural components | 36 | Scandinavia | 2007 |
| Rickel et al. (19) Perri et al. (20) Radcliff et al. (21) | F | 59 | 234 | Six-month group-based lifestyle program | Six-month group-based lifestyle program | Newsletters with tips and recipes | 6 | US | 2011 |
| Sjöström et al. (16) | M + F | 45 | 261 | 120 mg orlistat 3×/d for 1 yr plus hypocaloric diet | 120 mg orlistat 3×/d plus weight-maintenance diet | Placebo plus weight-maintenance diet | 12 | Europe | 1998 |
| Thomas et al. (22) | Not reported | 45 | 55 | Not reported (recruited from a weight loss clinic) | Weekly emails from a dietician with dietary, behavioural and exercise advice | No contact | 6 | UK | 2011 |
Note: F = female, M = male. *If a study included multiple treatment arms with different doses of orlistat, only the 120 mg group was included.