| Study | High-sensitivity troponin I assay | Conventional troponin T assay | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cut-off point and assay | Sensitivity | Specificity | NPV, % | PPV, % | Cut-off point and assay | Sensitivity | Specificity | NPV, % | PPV, % | |
| Reichlin et al. 2009 (9) | 40 ng/L ADVIA Centaur Immunoassay System (Siemens) | 0.89 | 0.92 | 98 | 68 | 0.035 ng/mL 4th generation (Roche) | 0.72 | 0.97 | 94 | 85 |
| Bhardwaj et al. 2011 (23) | 6.28 ng/L Erenna Immunoassay System (Singulex) | 0.57 | 0.86 | 89 | 50 | 0.03 ng/mL Elecsys 2010 or E170 platforms (Roche Diagnostics) | 0.22 | 0.97 | 84 | 65 |
| Keller et al. 2009 (24) | 40 ng/L Troponin I Ultra (Siemens Healthcare Diagnostics) | 0.91 | 0.90 | 96.4 | 76.7 | 0.03 ng/mL (Roche) | 0.64 | 0.97 | 88.3 | 88.8 |
Note: NPV = negative predictive value, PPV = positive predictive value.