| Variable | % (no.)* | p value | |||
|---|---|---|---|---|---|
| All patients (n = 369) | Centre 1 (n = 174) | Centre 2 (n = 114) | Centre 3 (n = 81) | ||
| Acute renal failure | 61 (224) | 62 (108) | 72 (82) | 42 (34) | < 0.001 |
| Myocardial infarction | 35 (128) | 33 (57) | 59 (67) | 5 (4) | < 0.001 |
| Maximal serum lactic acid ≥ 4.0 mmol/L | 35 (128) | 24 (41) | 48 (55) | 40 (32) | < 0.001 |
| ARDS or ALI | 31 (115) | 30 (53) | 39 (44) | 22 (18) | 0.049 |
| Cardiac arrhythmia | 24 (89) | 18 (32) | 22 (25) | 40 (32) | 0.001 |
| Maximal INR ≥ 2.0 | 23 (84) | 14 (24) | 34 (39) | 26 (21) | < 0.001 |
| Acute pulmonary edema | 17 (61) | 17 (29) | 11 (13) | 23 (19) | 0.08 |
| Massive hemorrhage | 13 (48) | 21 (37) | 9 (10) | 1 (1) | < 0.001 |
| Ischemic bowel disease | 6 (23) | 8 (14) | 4 (5) | 5 (4) | 0.5 |
| Stroke | 3 (10) | 2 (4) | 4 (5) | 1 (1) | 0.5 |
| No. of acute illnesses per patient, median (IQR) | 2 (1 to 3) | 2 (1 to 3) | 3 (2 to 4) | 2 (1 to 3) | < 0.001 |
| Patients with no concurrent acute illness | 9 (34) | 9 (15) | 4 (4) | 19 (15) | 0.002 |
| Patients with ≥ 1 concurrent acute illnesses | 91 (335) | 91 (159) | 96 (110) | 81 (66) | 0.002 |
| Patients with ≥ 2 concurrent acute illnesses | 72 (265) | 70 (121) | 85 (97) | 58 (47) | < 0.001 |
Note: ALI = acute lung injury, ARDS = acute respiratory distress syndrome, INR = international normalized ratio, IQR = interquartile range. *Unless stated otherwise.