Variable | % (no.) [95% CI]† | p value | |||
---|---|---|---|---|---|
All sites | Centre 1 | Centre 2 | Centre 3 | ||
No. of patients | 369 | 174 | 114 | 81 | – |
Total no. of targets analyzed | 604 | 277 | 176 | 151 | – |
Patients with ≥ 1 targets | 99 (365) [98 to 100] | 99 (173) [97 to 100] | 99 (113) [95 to 100] | 98 (79) [94 to 100] | 0.4 |
All targets‡ | n = 604 | n = 277 | n = 176 | n = 151 | < 0.001 |
SAP is only target | 16 (95) [13 to 19] | 6 (18) [4 to 9] | 43 (75) [35 to 49] | 1 (2) [0 to 3] | |
MAP is only target | 73 (438) [69 to 76] | 79 (220) [75 to 84] | 39 (69) [33 to 47] | 99 (149) [97 to 100] | |
SAP and MAP combined | 8 (50) [6 to 11] | 14 (38) [10 to 18] | 7 (12) [3 to 11] | (0) | |
Other | 3 (21) [2 to 5] | 0.4 (1) [0 to 2] | 11 (20) [7 to 16] | (0) | |
First target only§ | n = 365 | n = 173 | n = 113 | n = 79 | < 0.001 |
SAP is only target | 16 (58) [12 to 20] | 3 (6) [1 to 6] | 45 (51) [36 to 54] | 1 (1) [0 to 4] | |
MAP is only target | 75 (273) [70 to 79] | 83 (144) [78 to 89] | 45 (51) [36 to 54] | 99 (78) [96 to 100] | |
SAP and MAP combined | 7 (27) [5 to 10] | 13 (23) [8 to 18] | 4 (4) [0 to 7] | (0) | |
Other | 2 (7) [1 to 3] | (0) | 6 (7) [3 to 12] | (0) | |
Target value (first targets only) | |||||
SAP only, mm Hg, median (IQR) | 100 (90 to 100) n = 58 | 100 (90 to 100) n = 6 | 100 (90 to 10) n = 51 | 120 (120 to 120) n = 1 | 0.04 |
MAP only, mm Hg, median (IQR) | 65 (65 to 70) n = 273 | 65 (65 to 65) n = 144 | 65 (65 to 70) n = 51 | 70 (70 to 75) n = 78 | < 0.001 |
Note: CI = confidence interval, IQR = interquartile range, MAP = mean arterial pressure, SAP = systolic arterial pressure. *Vasopressor targets are values of physiologic variables (e.g., specific blood pressure values) that physicians set as goals of care and achieve by dosing continuous infusions of vasopressors. †Unless stated otherwise. ‡Denominator is total no. of targets analyzed. § Denominator is no. of patients with ≥ 1 targets.