RT Journal Article
SR Electronic
T1 Cannabis use during methadone maintenance treatment for opioid use disorder: a systematic review and meta-analysis
JF CMAJ Open
JO CMAJ
FD Canadian Medical Association
SP E665
OP E673
DO 10.9778/cmajo.20190026
VO 7
IS 4
A1 McBrien, Heather
A1 Luo, Candice
A1 Sanger, Nitika
A1 Zielinski, Laura
A1 Bhatt, Meha
A1 Zhu, Xi Ming
A1 Marsh, David C.
A1 Thabane, Lehana
A1 Samaan, Zainab
YR 2019
UL http://www.cmajopen.ca/content/7/4/E665.abstract
AB Background: Rates of cannabis use among patients receiving methadone maintenance therapy are high, and cannabis use may be associated with outcomes of methadone maintenance therapy. We examined the effect of cannabis use on opioid use in patients receiving methadone maintenance therapy to test the hypothesis that cannabis use is associated with a reduction in opioid use.Methods: In this systematic review, we searched MEDLINE/PubMed, Embase, PsycINFO, CINAHL and ProQuest Dissertations and Theses Global from inception to July 12, 2018. We summarized the effects of cannabis use on opioid use during methadone maintenance therapy and treatment retention. We conducted meta-analyses using a random effects model.Results: We included 23 studies in our review. We performed a meta-analysis of 6 studies, with a total number of participants of 3676, examining use of cannabis and opioids during methadone maintenance therapy. Owing to high heterogeneity, we described the studies qualitatively but provide the forest plots as supplemental material. The overall quality of evidence was very low, with a high risk of bias, owing to the nature of observational studies.Interpretation: We found no consensus among studies that cannabis use is associated with reduced opioid use or longer treatment retention when used during methadone maintenance therapy in patients with opioid use disorder. PROSPERO Registration: CRD42015029372