RT Journal Article
SR Electronic
T1 Development of a provisional essential medicines list for children in Canada: consensus process
JF CMAJ Open
FD Canadian Medical Association
SP E146
OP E150
DO 10.9778/cmajo.20170129
VO 6
IS 1
A1 Hannah Woods
A1 Efosa Oronsaye
A1 Anjli Bali
A1 Yathavan Rajakulasingam
A1 Taehoon Lee
A1 Norman Umali
A1 Eyal Cohen
A1 Yaron Finkelstein
A1 Martin Offringa
A1 Nav Persaud
YR 2018
UL http://www.cmajopen.ca/content/6/1/E146.abstract
AB Background: Worldwide, many countries have developed a list of essential medicines for children to improve prescribing. We aimed to create an essential medicines list for children in Canada.Methods: We adapted the previously created preliminary list of essential medicines for adults in Canada and the WHO Model List of Essential Medicines for Children to create a provisional list of essential medicines for children in Canada. Canadian clinicians made suggestions for changes. Literature relevant to each suggestion was presented to clinician-scientists, who used a modified nominal group technique to make recommendations on the suggestions. Ontario Public Drug Programs prescription data were reviewed to identify commonly prescribed medications missing from the list. Literature relevant to these medications was shared with a clinician-scientist review panel to determine which should be added, and a revised list was developed.Results: A total of 76 items were removed from the list of essential medicines for adults in Canada because they were not indicated for use in children or were not relevant in the Canadian health care context; 7 medications were added to the child list based on Ontario Public Drugs Programs prescribing data and clinician-scientist review. Suggestions to add, remove or substitute medications were made by peer-reviewers and resulted in removal of 1 medication and replacement of 1 medication. The process produced a provisional list of 67 essential medications for children.Interpretation: A provisional list of 67 essential medicines for children was created through a peer-reviewed, multistep process based on current clinical evidence, Canadian clinical practice guidelines and historical prescribing data. It is publicly posted at http://cleanmeds.ca/. The list should be further developed based on wider input and should be continuously revised based on emerging evidence of the safety and effectiveness of these medicines in all pediatric age groups.